Clinical chemistry laboratory
The clinical PET laboratory provides high quality services for academic and commercial PET research projects. All laboratory work is carried out in accordance to Good Clinical Laboratory Practices (GCLP) and Good Clinical Practices (GCP). We participate in planning and completing comprehensive academic and commercial projects while developing new project-specific tailored methods when required.
Administration of the radiopharmaceuticals
The preparation of injecting syringes for administrating various 11C-, 18F- and 68Ga-radiopharmaceuticals is performed manually in a clean room laminar flow hood. Semi-automatic multi-dose administration system KARL 100 is used to fill the most common 18F-labelled radiopharmaceuticals into injection syringes. 15O-based radiopharmaceuticals are produced with the IBA Cyclone 3 cyclotron and administered automatically into the subject during the PET scan.
Radioactivity measurements
The total radioactivity of whole blood, plasma, blood cells, tissue and urine samples are obtained using an automated Hidex AMG gamma counter. Arterial blood radioactivity concentration is measured with a GE FRQ automatic blood sampling system while imaging.
Radiometabolite and protein binding analysis
The fractions of radioactive metabolites and the unchanged parent radiopharmaceutical fraction are analysed from plasma, and in some cases urine samples, with radio-HPLC and radio-TLC to achieve the true input function for kinetic analysis and quantification of PET images. For studying and understanding the kinetics and ADME (Absorption, Distribution, Metabolism, Excretion) properties further of new tracers, the radiometabolite and tracer-protein binding analysis can be performed to allow further insights in to pharmacokinetic modelling.
Other services
An integral part of the PET laboratory services relates to sample handling, storing and sending to be analysed globally. Other on-site laboratory analyses can be performed on request such as the blood glucose concentration during hyperinsulinemic-euglycemic clamping.
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